Oct 2026· International Journal of Biological Macromolecules· pp.
154850
· 0 citations
Medicine
TL;DR
Zein-based gene delivery remains preclinical and requires stronger mechanistic, cargo-specific and route-specific validation, and translational rationale for zein lies not in superior intrinsic transfection efficiency, but in route-specific protection, sustained release, hydrophobic drug co-loading and use as a biodegradable scaffold within multifunctional hybrids.
ABSTRACT Polyplexes are versatile, efficient nonviral vectors for gene-based therapies and offer safer alternatives to conventional viral delivery systems. Delivering nucleic acids, including DNA, RNA, and siRNA, remains challenging because of limited stability, cellular uptake, and intracellular trafficking. Formed th...
Hamaira Liaqat, Huma Hameed, Syed Muhammad Ahmad et al.· Polymer-Plastics Technology...· 0 citations
Various functionalized nanocarriers for gene delivery including silica-based nanoparticles, gold NPs, magnetic NPs, graphene-based materials, carbon nanotubes, polycationic systems, and lipidic nanostructures are summarized.
Houra Nekounam, Ali KarbalaeiMahdi, Faranak Mohammadi et al.· Nanotechnology· 0 citations
Small interfering RNA (siRNA) therapeutics have emerged as a transformative approach for sequence-specific gene silencing, offering the potential to treat a broad spectrum of diseases by selectively suppressing disease-associated genes. However, the clinical translation of siRNA remains limited by rapid enzymatic degra...
G. S. Amrish Varshan, S. Namasivayam· Nanomedicine: Nanotechnology...· 0 citations
The importance of formulation optimization in improving nucleic acid delivery is highlighted and practical insights for enhancing peptide- and lipid-based therapeutic platforms are provided.
D. Daniele, Z. Hein, O. Saher et al.· International Journal of Pha...· 0 citations
Current strategies, namely molecular modification, crosslinking, surface shielding and structural optimization of PEI-based gene-delivery system are explored for enhancing the safety and therapeutic promise of this platform.
S. R, S. R., V. K et al.· Advanced International Journ...· 0 citations
Delivering therapeutic macromolecules to defined cell populations in vivo remains a central unsolved problem in biomedicine. Proteins, nucleic acids and viral vectors are cleared by phagocytes, degraded by enzymes, blocked by endothelial and interstitial barriers, and trapped in acidifying endolysosomes. Pre-existing i...
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
