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Tripartite Interplay of Epithelial, Immune, and Microbiota Dysregulation in Crohn's Disease: Mechanisms and Translational Strategies

Oct 2026 · Immunity, Inflammation and Disease · Vol 14 · 0 citations · 48 references
Medicine

TL;DR

Cumulative evidence supports the role of the intestinal epithelial barrier, immune system and gut microbiota in the progression of Crohn's disease.

Abstract

Crohn's disease (CD) is a multifactorial inflammatory bowel disease (IBD) characterized by impaired epithelial barrier integrity, excessive immune hyperactivation, and gut microbiota perturbations. Cumulative evidence supports the role of the intestinal epithelial barrier, immune system and gut microbiota in the progression of CD.

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