This study provides a list of metabolites altered in the seminal fluid of infertile men, highlighting their potential as biomarkers of male infertility, and gives insights into the metabolic pathways affected in these conditions.
Background Idiopathic male infertility (IMI) accounts for 30%–40% of male infertility cases, yet the molecular networks associated with seminal plasma dysfunction and non-invasive biomarkers remain largely unclear. This study aimed to preliminarily explore the transcriptomic and metabolomic alterations in IMI seminal p...
Chao Du, Xiao-Yue Zhai, Xin-Yue Fan et al.· Frontiers in Endocrinology· 0 citations
Tyrosol notably enhanced sperm performance, suggesting its potential integration into clinical strategies for AZS management and fertility preservation and the dysregulation of the metabolite tyrosol, which is associated with AZS.
Dan-Na Chen, Ying-Ge Fu, Yan-Ting Wang et al.· Asian Journal of Andrology· 0 citations
Background:
Female infertility is a multifactorial condition with significant medical and social implications. Despite advances in the diagnosis and treatment of infertility, reliable biomarkers for early detection and selection of personalized therapy remain limited. Objective: To evaluate the role of metabolomic b...
F. I. Shukurov, M. A. Yuldasheva, M. D. Abdurazakova et al.· Innovative Medicine of Kuban· 0 citations
Idiopathic male infertility (IMI) usually refers to abnormal semen parameters after known causes have been excluded. However, its clinical stratification and intervention evidence remain difficult to reconcile. Based on low biomass in semen, this review proposes an SD–IO–SDF axis linking seminal dysbiosis (SD), inflamm...
Background: Infertility is a highly significant problem in women with severe endometriosis and the molecular characteristics of infertile versus fertile women with advanced endometriosis have not been fully characterized. Methods: We reanalyzed the whole normalized Series Matrix (36 secretory-phase endometrial samples;...
Sher Muhammad· Natural Resources for Human...· 0 citations
Background: Male infertility is a pressing clinical and social issue, affecting approximately 30–50% of infertile couples. Despite extensive research, the etiology remains unknown in a considerable proportion of cases, underscoring the need for molecular genetic investigations into spermatogenesis disorders. Methods: t...
N. Kulchenko, G. Myandina, H. Alhejoj et al.· Medical Science· 0 citations
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