By repurposing Flavoxate, this work proposes a clinically translatable strategy to mitigate NLRP3-mediated neuroinflammation in AD, offering a potential disease modifying therapy with an established safety profile and underscores the significance of computational approaches in bridging the gap between preclinical discovery and therapeutic application for neurodegenerative diseases.
Bitter taste receptors, particularly TAS2R14, are widely expressed in extraoral tissues, including the central nervous system, where they have been implicated in neuroinflammatory and neurodegenerative processes. Although numerous pharmacological and natural compounds have demonstrated therapeutic potential against neu...
Background and Objectives: Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and current therapies provide only limited symptomatic relief without effectively slowing its progression. Increasing evidence suggests that aberrant activation of the Janus kinase/signal transducer and activator of trans...
L. T. Nguyen, Mai Thi Nguyen, T. Nguyen· Medicina· 0 citations
Computational findings suggest that ligand 4 represents a promising alkynyl-3-carboxamide-based lead scaffold for further development as a potential legumain-targeted therapeutic candidate for AD.
Afifa Noor, H. N. Suha, Istiak Hossain et al.· Physical Chemistry, Chemical...· 0 citations
This study identifies structurally tractable TQ analogs with improved predicted potency and establishes a robust computational framework for neuroprotective discovery as redox‐modulating agents in ALS.
Jabir C Nalicho, P. Mabeyo, Andrew S. Paluch et al.· ChemistryOpen· 0 citations
The NLRP3 inflammasome (NLR family pyrin domain-containing 3) plays a central
role in the pathogenesis of several chronic inflammatory diseases, including rheumatoid
arthritis, type 2 diabetes mellitus, and Alzheimer disease. However, currently available
inhibitors, such as MCC950, present important limitations related...
Nalberth B. Farias, J. D. da Rocha, R. D. de Barros et al.· Journal of the Brazilian Che...· 0 citations
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