Oct 2026· Journal of Molecular Neuroscience· Vol 76· 0 citations· 54 references
Medicine
TL;DR
It is suggested that temporal lobe epilepsy with hippocampal sclerosis comprises partially distinct molecular contexts that may converge on a common histopathological endpoint, and molecular heterogeneity within a shared histopathological diagnosis is highlighted.
Disrupted immune balance and neuroglial–vascular cell homeostasis in vascular dementia is revealed, and ELF2 is prioritized as a candidate regulator associated with immune heterogeneity in VaD.
Li Liang, Cui-Qin Shen, Shi-Ren Huang et al.· Medicine· 0 citations
The mechanisms underlying type 2 diabetes-associated cognitive dysfunction (DACD) remain poorly understood, hindering therapeutic progress. Here, we integrated spatial transcriptomics and single-nucleus RNA sequencing to delineate the spatiotemporal molecular and cellular landscape of DACD in brain tissues from 3- and...
Wei Wu, Yu-Meng Yang, Xi-Xi Zhang et al.· Proceedings of the National...· 0 citations
BACKGROUND
Perioperative neurocognitive disorders (PND) and Alzheimer's disease (AD) are both important aging related cognitive disorders. Accumulating evidence suggests that they share common pathological mechanisms involving Aβ deposition, neuroinflammation, and immunometabolic imbalance. However, the key regulatory...
Shan Yang, Dan Wu, Yan-Jun Li et al.· Biochemical and Biophysical...· 0 citations
Ast.1 is defined as a pivotal driver of microenvironmental collapse in AD, unveiling a novel microglia-astrocyte-neuron pathogenic cascade mediated by the ROS-xCT metabolic hub.
Xue-Man Xie, Wen-Jing Liu, Long-Chao Chen et al.· Life Science· 0 citations
The potential of proteomics to characterize the molecular complexity of AD and reveal interconnected changes across different levels of disease biology is demonstrated, supporting a view of AD as a progressive disruption of cellular and intercellular communication and emphasizing the need for multi-targeted approaches...
It is shown that depletion of these AD risk genes disrupts baseline morpho-transcriptomic coupling and fundamentally alters microglial phagocytic capacity, revealing how AD GWAS genes may drive microglia into dysfunctional states characterized by altered morphology, distinct multi-omic signatures, and impaired function...
Ying-Jie Zhang, Ai Zhang, Sang Seo et al.· bioRxiv· 0 citations
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