Oct 2026· Cancer Cell· Vol 44 10, pp.
1916-1917
· 0 citations· 9 references
Medicine
TL;DR
A microbiota-orchestrated stem-like lymphoid niche in which CD70+ ILC2s sustain progenitor exhausted T cells is uncovered, and its findings redefine the functional organization underlying TLS-associated antitumor immunity.
Abstract
While tertiary lymphoid structures (TLSs) broadly correlate with immunotherapy efficacy, their functional heterogeneity can translate into divergent clinical outcomes. In this issue of Cancer Cell, Hu et al. uncover a microbiota-orchestrated stem-like lymphoid niche in which CD70+ ILC2s sustain progenitor exhausted T cells, and their findings redefine the functional organization underlying TLS-associated antitumor immunity.
It is discovered that cytotoxic CD4+ T cells foster this process via the CCL5–CCR5 axis and it is found that the clinically approved CCR5 antagonist maraviroc can rebalance immunity in aged mice.
Ringham et al.1 identify CHL1+CXCL9+ cancer-associated fibroblasts at lung tumor margins that recruit suppressive CXCR3+ regulatory T cells, revealing how stromal chemokine gradients can promote immune evasion. Viewed alongside immune-stimulatory CCL19+ fibroblastic reticular cells, these findings suggest that immune-i...
L. Onder, Hung-Wei Cheng, B. Ludewig· Developmental Cell· 0 citations
In this issue of Cell, Howard et al. reveal how the milk glycoprotein osteopontin shapes the neonatal microbiome to regulate hematopoiesis, promoting dendritic cell development and protection from severe respiratory infection. These findings uncover a maternal milk-microbiota pathway linking early-life nutrition to imm...
Evidence is provided for a key role of TNFR1, as expressed by malignant cells, in orchestrating a pro-tumor immunosuppressive environment through secondary inflammatory mediators through secondary inflammatory mediators.
Elixabet Bolaños, Lorena Cañas-Zabala, Irene Olivera et al.· Journal of Experimental Medi...· 1 citation
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