Open access
TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment
Elixabet Bolaños
Lorena Cañas-Zabala
Irene Olivera
David Ruiz Guillamón
Enric Vercher
Gabriel Gomis
C. D. de Andrea
Raluca Alexandru
Arantza Azpilikueta
Nekane Soria
Dayanna Salinas
Paula Molero-Glez
Carlos Luri-Rey
Saioa Arrieta-Aranzueque
Almudena Manzanal
M. García-Domínguez
D. Alignani
B. Ségui
Á. Molina
Á. Teijeira
P. Berraondo
I. Melero
Medicine
Abstract
This study provides evidence for a key role of TNFR1, as expressed by malignant cells, in orchestrating a pro-tumor immunosuppressive environment through secondary inflammatory mediators. Results highlight the relevance of interfering TNFα/TNFR1 in cancer immunotherapy.