Meta-analyses of the NEPTUNE dataset related to high and low risk FSGS and cellular APOL1 models identifies Calcium signalling, mTOR signaling and inflammation-associated pathways as operative in APOL1-mediated kidney disease

Multi-omics characterization of anoikis-related hub genes and macrophage-centered immune persistence with validation of HAVCR2 in atherosclerosis

A macrophage-centered anoikis-related immune signature in atherosclerosis is defined and HAVCR2 is identified, together with CD36, PLAU, TNF, PYCARD, SERPINA1, BLNK, and CHI3L1, as potential biomarkers and candidate targets for future diagnostic and therapeutic investigation.

TET2 promotes monocyte inflammatory activation in asthma via ALKBH5-m6A regulation and PI3K signaling: evidence from m6A-SNP and single-cell analyses

This study establishes TET2 as a key m6A-regulated gene linking genetic susceptibility to monocyte-driven inflammation, and highlights the ALKBH5-m6A-TET2 axis as a potential therapeutic target for modulating aberrant immune responses in asthma.

Mendelian randomization and single-cell transcriptomics prioritize CD7 and LAPTM5 in primary Sjögren's disease: an integrative multi-omics analysis.

Stage-specific ROMO1 in rheumatoid arthritis: predictive immune insights into the MIF pathway and HLA-DR/IL2RA axis via integrated GWAS, transcriptomic, single-cell, and spatial profiling.

Emerging evidence links reactive oxygen species modulator 1 (ROMO1), a key mitochondrial ROS regulator, to rheumatoid arthritis (RA) pathogenesis. However, its exact mechanism remains elusive given the conflicting evidence about its specific function. We used a four-level integrative framework combining multi-omics dat...

Integrated analysis of bulk transcriptomics and single-cell transcriptomics revealed the association characteristics between heart failure and β-hydroxybutyrylation-related genes

Functional enrichment analyses demonstrated that HMOX2 and KPNA2 were identified as Kbhb-related biomarkers in HF, while T cells served as a key cell type in the disease, and novel therapeutic targets for HF patients were provided.

Network Pharmacology Reveals MAPK- and RTK-mediated Erythropoietic Signalling as a Shared Mechanism of Dapagliflozin and Empagliflozin

Sodium-glucose cotransporter-2 (SGLT-2) inhibitors consistently raise haemoglobin and haematocrit in patients with type 2 diabetes, heart failure and chronic kidney disease, and post-hoc mediation analyses suggest that this haematological shift accounts for a substantial fraction of their cardiovascular benefit. Th...