TL;DR
It is discovered that Epstein-Barr virus (EBV), the oncogenic driver of nasopharyngeal carcinoma (NPC), requires ADAR1 both to maintain latent infection and for lytic reactivation by preventing PKR-mediated ISR activation.
ABSTRACT The intricate interplay between co-infecting viral pathogens within a host can significantly influence disease outcomes. Dengue virus (DENV), a globally prevalent arbovirus from the Flaviviridae family, and Epstein-Barr virus (EBV), a ubiquitous human herpesvirus, share extensive geographical overlap, yet thei...
It is shown that PRF functions as a regulatory signal that rewires host translation in favor of viral replication, highlighting PRF as a stress-inducing module that enhances viral replication.
Human cytomegalovirus (CMV) and BK polyomavirus are archetypal latent DNA viruses that establish lifelong persistence and cause severe disease upon reactivation in immunocompromised hosts. Although they differ markedly in virion architecture, genome size, and coding capacity, both viruses converge on a shared biologica...
This review examines the diverse yet convergent immune evasion strategies employed by major neurotropic RNA and DNA viruses, including herpes simplex virus, varicella-zoster virus, cytomegalovirus, rabies virus, rabies virus, flaviviruses, alphaviruses, enteroviruses, and JC virus.
Double-stranded RNA (dsRNA) reoviruses are primarily sensed by the RIG-I-like receptor (RLRs) signaling pathway. However, whether these viruses can also activate the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, a central DNA-sensing system, remains poorly understood. Grass carp r...
Epstein–Barr Virus (EBV) is an oncogenic gammaherpesvirus present in >95% of the adult population. EBV is responsible for nearly 2% of the global cancer burden and is a contributing factor in the development and progression of both epithelial and lymphoid malignancies. Throughout its lifecycle, EBV manipulates the DNA...
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