Isorhoifolin attenuates cadmium-induced hepatotoxicity by modulating TLR4/MyD88/TRAF6/NF-κB and Nrf2/Keap1 pathways: a biochemical and histological study
Results showed that Cd exposure substantially downregulated BCL-2 mRNA expression, upregulated the apoptotic proteins BAX and CASPASE-3, and caused severe histopathological damage, but IRF attenuated all the above-mentioned damages and preserved hepatic tissue architecture.
Overall, KM showed promising therapeutic properties against Cd-instigated cardiotoxicity in rats via restoring antioxidant status as well as suppressing inflammation and apoptosis.
M. U. Ijaz, R. Azmat, Moazama Batool et al.· Journal of Trace Elements in...· 0 citations
Introduction Cadmium (Cd) toxicity is one of the major public health problems because of its long half-life (10–30 years). Exposure to Cd can cause toxicity that affects several organs, including the liver and the kidney. Saroglitazar is highlighted in this study as a potential preventative medication against hepatic-r...
A. Alanazi, Hoda E. Kafl, Dalia H. El-Kashef et al.· Frontiers in Pharmacology· 0 citations
TXA effectively protects against isotretinoin-induced hepatotoxicity, primarily through antioxidant and anti-inflammatory mechanisms, primarily through antioxidant and anti-inflammatory mechanisms.
Abdullah Alkhammash, H. Hagar, Hatem Ali Ahmed Abdelmottaleb et al.· Immunopharmacology and immun...· 0 citations
Cadmium (Cd) is a highly toxic compound that induces deleterious effects on living organisms and causes multi-organ toxicity, including testicular damage. Kumatakenin (KMK) is a flavonoid with potential antioxidant and anti-inflammatory properties. The present study was designed to assess the protective effects of KMK...
Muhammad Umar Ijaz, M. Salar, Moazama Batool et al.· Steroids· 0 citations
It is found that Cd promoted lipid accumulation, disrupted lipid metabolism, and thereby induced renal immunosuppression, and LBP effectively alleviated Cd-induced renal injury, suggesting beneficial effects against Cd-triggered nephrotoxicity.
Xue-Ru Wang, Dong-Di Liu, Yong-Gang Ma et al.· Frontiers in Veterinary Scie...· 0 citations
Interestingly, the LYP co-administration abrogated the CPM-induced oxidative stress, proinflammation, apoptosis, and DNA fragmentation and indicates that LYP supplementation may protect the kidney from oxidative stress-related attacks of CPM.
Nourah Almulhim, Manal Alfuwaire, H. Elsawy et al.· Avicenna Journal of Phytomed...· 0 citations
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