Characterization of Mmp37p, a Characterization of Mmp37p, a Saccharomyces cerevisiae Mitochondrial Matrix Protein with a Role in Mitochondrial Protein Mitochondrial Matrix Protein with a Role in Mitochondrial Protein Import Import
It is hypothesize that the presence of Mmp37p enhances the early stages of the TIM23 matrix import pathway to ensure engagement of incoming preproteins with the mtHsp70p/PAM complex, a step that is necessary to drive the unfolding and complete translocation of the preprotein into the matrix.
The solution structure of mature Saccharomyces cerevisiae Mba1 is determined using multidimensional nuclear magnetic resonance (NMR) spectroscopy and reveals a compact α + β fold with a central hydrophobic cavity and distinct charged surface regions, providing a structural framework for interpreting previous functional...
Jing Yang, Mao-Sen Ruan, Dong-Shuai Bai et al.· Journal of Structural Biolog...· 0 citations
It is concluded that FAM136A is an IMS-resident chaperone, necessary and sufficient to maintain nascent membrane proteins in a folding-competent state to mediate their integration into the bilayer.
M. Ernst, Jichen Zhang, Haoqi Xu et al.· bioRxiv· 0 citations
The data support a model in which the MTCH2-ARMC1 interaction functions as a metabolic switch during starvation to regulate the balance between fat storage and fat burning.
Andrew Castonguay, Dariel Márquez, Andrew M. Natale et al.· bioRxiv· 0 citations
These findings redefine trypanosomal p22 as a dual-function coordinator of mitochondrial gene expression and reveal that the ancestral role of the p32 family is associated with mitochondrial translation.
Prashant Chauhan, Ingrid Sveráková-Škodová, J. T. Wong et al.· bioRxiv· 0 citations
This study comprehensively elucidated the role of the presequence and the mature part of mitochondrial precursors in the cytosol, by use of a cytosol-targeted MPP which prematurely processed mitochondrial precursors.
It is demonstrated that Djp1 is a regulator of Phosphatidylserine decarboxylase 1 (Psd1), an inner mitochondrial membrane resident responsible for mitochondrial phosphatidylethanolamine production, and the combined loss of Djp1 and Psd1 results in a synthetic sick phenotype that unexpectedly reflects a role(s) for Djp1...
Rashima Prem, Alex Maya-Romero, C. Xie et al.· bioRxiv· 0 citations
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