Epithelial antigen presentation shapes barrier memory

Dendritic cells sense microbial adhesion to launch innate immunity

This work has identified a first phase of innate immune defense that is driven by mechanical signals and recruits neutrophils before Toll-like receptor signaling becomes dominant.

A tolerogenic function for gut TFH cells

Innate lymphoid cells as central regulators of tissue homeostasis: implications for allergic diseases

New cancer vaccine approach directly targets dendritic cells

Barrier immune memory is programmed by intestinal epithelial cell presentation of cytosol-delivered bacterial antigens

Antigen compartmentalization is known to influence CD4 and CD8 T cell recognition but its impact on immune responses to different antigens expressed by the same pathogen is poorly understood. By tracking the clonal CD4 T cell response to a single epitope shuttled between different virulence proteins of Citrobacter rode...

Cytotoxic CD4+ T cells support age-associated myelopoiesis

It is discovered that cytotoxic CD4+ T cells foster this process via the CCL5–CCR5 axis and it is found that the clinically approved CCR5 antagonist maraviroc can rebalance immunity in aged mice.