TL;DR
This work has identified a first phase of innate immune defense that is driven by mechanical signals and recruits neutrophils before Toll-like receptor signaling becomes dominant.
Antigenic and environmental stimuli sensed by innate and adaptive immune cells trigger cognate functions that allow the coordination of the appropriate immune response. In this issue of Immunity, Tzerpos et al. and Jay et al. demonstrate that chromatin architecture dynamics integrate sensory inputs with functional outp...
A little-known arm of the immune system respond to lipids, with a protein called CD1 driving reactions to bee stings, bacteria, and possibly poison ivy.
It is shown that the mouth is a reservoir for fungal Th17 cells that adopt pathogenic signatures in the gut during Crohn's disease.
Toll-like receptors (TLRs) are central players of the host innate immune system, functioning as germline-encoded pattern recognition receptors (PRRs) that monitor extracellular and endosomal environments [...].
In this issue of Cell, Howard et al. reveal how the milk glycoprotein osteopontin shapes the neonatal microbiome to regulate hematopoiesis, promoting dendritic cell development and protection from severe respiratory infection. These findings uncover a maternal milk-microbiota pathway linking early-life nutrition to imm...
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