Results indicated that increased Nrf2 expression reduced IIR-induced intestinal apoptosis and that the protective function of Nrf2 may be based on its anti-inflammatory effects through the inhibition of the NF-κ B pathway.
It is shown for the first time that Ufm1 is upregulated in LPS-induced inflammation and Ufm1 plays an inhibitory role in inflammatory responses by targeting NF-κ B nuclear translocation, suggesting Ufm1 may be a novel gene that protects against inflammatory responses.
Yuan-Yuan Li, Guang-Ya Zhang, Jiangping He et al.· 0 citations
Extracellular matrix metalloproteinase inducer (CD147) has been proven to play a crucial role in a variety of inflammatory diseases but has not yet been investigated in trauma. The aim of the study was to investigate the role of CD147 in a murine model of trauma and hemorrhagic shock (TH) on the activation of NF-κB, as...
F. Bläsius, Kang Qin, You Li et al.· Scientific Reports· 0 citations
Hepatic ischemia-reperfusion injury (HIRI) remains a critical complication in liver surgery with limited pharmacological options, and while Farrerol (FA), a natural dihydroflavone, has shown protective effects in other organ IR models, its role in HIRI has never been explored. In this study, we established a murine mod...
Hong-Liang Liang, Jian-Sen Lu, Hao Pan et al.· International Immunopharmaco...· 0 citations
TLR3 overexpression significantly alleviated acute liver injury and apoptosis in GalN/LPS-induced acute liver injury models, and was associated with increased AMPK phosphorylation and elevated IRF3 expression in both in vivo and in vitro experiments.
Yi Zhang, Jun Zou, Xiang Chen· Discover medicine· 0 citations
Clinically, elevated urinary CCL2 in critically ill children associates with higher risk of concurrent AKI/ALI and poorer prognosis, indicating CCL2 as a biomarker for treatment response and prognosis.
Results underscore the potential of morin in modulating molecular responses associated with lead-induced hepatotoxicity, and reveal strong binding affinities of morin with key inflammatory and apoptotic targets, suggesting potential molecular interactions that may contribute to its observed protective effects.
Reena Sheoran, A. Beniwal, Annu Phogat et al.· Chemical biology letters· 0 citations
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