Dopamine modified hyaluronic acid and chitosan/gallic acid grafted chitosan based hydrogel with antibacterial and antioxidant property for wound dressing.
An innovative multifunctional hydrogel was developed by incorporating dopamine-modified hyaluronic acid and gallic acid-modified chitosan and exhibited a porous microstructure, elastic solid-like mechanical behavior, and effective antibacterial activity against both Gram-negative and Gram-positive bacteria.
Abstract
The healing of chronic wounds remains a complex and challenging clinical issue. Antioxidant and antibacterial treatments play a crucial role in facilitating the wound healing process. Multifunctional hydrogels derived from natural products have shown promising potential in promoting skin tissue regeneration. In this study, a composite multifunctional hydrogel (CS/CSGA-DAHA) was developed by incorporating dopamine-modified hyaluronic acid (DAHA) and gallic acid-modified chitosan (CSGA), crosslinked through a combination of poly-electrolyte interactions and Schiff base reactions. The resulting hydrogel exhibited a porous microstructure, elastic solid-like mechanical behavior, and effective antibacterial activity against both Gram-negative and Gram-positive bacteria. Furthermore, the cytocompatibility of the hydrogel was confirmed through CCK-8 assay and fluorescent imaging analysis after co-cultivation with L929 fibroblast cells. This research introduces an innovative multifunctional hydrogel with promising potential as a wound dressing for various applications in chronic wound management.
Findings suggest that the synthesized hydrogel (BSG‐CHI) provides a favorable microenvironment for tissue regeneration and wound management applications.
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A multifunctional hydrogel patch developed by chemically modifying chitosan with N-acetylsulfonyl chloride and forming a cross-linked network with polyvinylpyrrolidone (PVP) represents a promising multifunctional dressing for the effective management of infected wounds.
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Stable hydrogel formation with favorable porous architecture, swelling behavior, thermal stability, and homogeneous distribution of nanovesicles was well established and exhibited excellent biocompatibility, hemocompatibility, and enhanced cell-material interactions.
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Impaired healing of chronic wounds typically stems from persistent oxidative stress, bacterial infection, and cellular dysfunction. Designing a multifunctional hydrogel dressing capable of adhesion, antioxidant activity, antibacterial ability, and cytocompatibility has demonstrated potential in wound healing applications. In this study, HTP composite hydrogels were fabricated based on thiolated chitosan (TCS) and methacrylated hyaluronic acid (HAMA) by incorporating polyethylene glycol diacrylate (PEGDA) and gelatin via the synergistic crosslinking of thiol-Michael addition and free-radical photopolymerization. Comprehensive characterization revealed that the hydrogel possessed an interconnected porous microstructure, appropriate swelling properties, and controllable degradation profiles, accompanied by pronounced shear-thinning behavior and tissue-adhesive capabilities. The obtained hydrogels demonstrated significant antibacterial activity against Staphylococcus aureus and Escherichia coli. Furthermore, the HTP hydrogels exhibited remarkable antioxidant capacity, scavenging DPPH and ABTS radicals. Additionally, the intracellular reactive oxygen species (ROS) scavenging ability was validated using NIH-3 T3 cells. Hemolysis assays and cytocompatibility evaluations confirmed the favorable hemocompatibility of the HTP hydrogels, which significantly promoted fibroblast proliferation and migration, indicating their substantial potential for wound healing applications.
Lei Nie, Xinran Li, Mengfei Feng et al.· International Journal of Bio...· 0 citations
It is demonstrated that the catechol-nanocellulose/chitosan polymeric hydrogel effectively overcomes adhesion, infection, and oxidative stress barriers in diabetic wound healing, making it a promising candidate for difficult-to-heal chronic ulcers.
A multifunctional composite hydrogel (GelDA/OPL) with excellent adhesion, self-healing properties, injectability, and photothermal antibacterial activity through Schiff base crosslinking between dopamine-modified gelatin (GelDA) and oxidized pullulan (OPL) is constructed.
Chen Zhang, Surui Yang, Zhi Xu et al.· Journal of materials chemist...· 0 citations