Conserved herpesvirus protein kinase (CHPK)-mediated phosphorylation of viral proteins associated with nucleocytoplasmic trafficking during natural infection
Analysis of viral gene expression, protein abundance, and post-translational modifications (PTMs) during natural infection suggests that MDV CHPK orchestrates the subcellular localization of multiple viral proteins in epithelial skin cells via phosphorylation, thereby enabling efficient replication and horizontal transmission in the natural host.
Marek’s disease virus (MDV) UL47 tegument protein 5 (UL47_TEG5) is a major tegument protein essential for viral replication and horizontal transmission in chickens. The protein undergoes dynamic nucleocytoplasmic shuttling, likely regulated by host and viral factors, including post-translational modifications (PTMs). P...
Flaviviruses are enveloped, positive-strand RNA viruses that cause millions of infections in the human population annually. Although Zika virus (ZIKV) had been detected in humans as early as the 1950s, its reemergence in South America in 2015 resulted in a global health crisis. While flaviviruses encode 10 proteins tha...
I. Manuelyan, Anna M. Schmoker, B. Yount et al.· PLoS Pathogens· 0 citations
The existing mechanistic knowledge about the PTBP1 functions during viral infection is described and the possibility of PTBP1 being used as a host-directed antiviral drug target despite the hurdles in doing so considering its multifunctionality as an essential cellular RNA-binding protein is explored.
Viruses encode RNA-binding proteins (RBPs) to manipulate host processes and promote infection. However, due to limited genomic space, many viral proteins are multifunctional and may engage RNA through non-canonical domains, making their identification difficult using traditional sequence-based approaches. Kaposi’s sa...
Yang Zhao, Xiang Ye, Madeline Yuen et al.· Nature Communications· 0 citations
ABSTRACT Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular processes, including the interfero...
Maxime Chazal, A. Sow, Elodie le Seac'h et al.· Journal of Virology· 0 citations
Newcastle disease virus (NDV), a significant avian paramyxovirus, depends on the acquisition of host-derived membranes for viral envelope assembly during budding. However, the relationship between NDV budding efficiency and host metabolic reprogramming remains incompletely understood. Our previous research demonstrated...
Jun Dai, Fan-Xin Liu, Yiyi Feng et al.· Poultry Science· 0 citations
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