The Histone Methyltransferase KMT2D promotes Natural Killer cell effector molecule release

Tecomin enhances natural killer cell effector activity with associated changes in cytolytic molecules and intracellular signaling pathways.

Natural killer (NK) cells are critical effectors of innate antitumor immunity; however, their therapeutic potential is limited by insufficient expansion, functional exhaustion, and variable cytotoxic activity. Plant-derived small molecules have emerged as attractive immunomodulators capable of enhancing NK-cell functio...

FTO promotes human NK cell proliferation yet restricts effector functions.

Role of PRDM1 in natural killer cells

SAHA modulates MICA and ULBPs expression on JEG-3 cells and enhances their susceptibility to NK cell-mediated cytotoxicity

Pregnancy is characterized by the emergence of a unique immunotolerant microenvironment that supports fetal development. Trophoblast cells and natural killer (NK) cells cooperate to establish the microenvironment essential for successful embryo implantation. Potential participants in this process include the activating...

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection.

Natural killer (NK) cells are innate immune cells that eliminate virus-infected and tumour cells by a plethora of signalling pathways, involving the production of cytokines and cytotoxic molecules. NK cell activation and functions demand substantial energy and fatty acids are energy-rich molecules reported to be import...

Attenuating NKG2D stimulation reshapes intratumoral NK cell functional state to enhance persistence and anti-tumor efficacy.

NK cell-based therapies for solid tumors are limited by poor persistence and progressive functional impairment. Here, we investigated how the strength of NKG2D stimulation shapes NK cell fate and therapeutic efficacy. Using B10G5, a MICA/B-targeting partial agonist antibody that attenuates NKG2D stimulation, we show th...