[LCN2 knockout protects endothelial barrier function in mice with sepsis-induced acute lung injury by regulating the NF-κB signaling pathway].

Sirtuin 3 attenuates sepsis-induced acute lung injury by suppressing NF-κB/NLRP3/GSDMD-mediated pyroptotic signaling.

BACKGROUND Sepsis is a major global health threat and frequently leads to acute lung injury (ALI). Pyroptosis has been increasingly implicated in the inflammatory progression of sepsis-induced ALI. Sirtuin 3 (Sirt3), a mitochondrial deacetylase, can regulate inflammatory injury and cellular stress responses. However, i...

GNG7 attenuates inflammation and modulates macrophage function via the NF-κB/NLRP3 inflammasome pathways in Poly I:C-induced acute lung injury.

Acute lung injury (ALI) is driven by excessive inflammation, but the molecular regulation of macrophage responses remain incompletely defined. This study investigated the role of G protein gamma subunit 7 (GNG7) in mediating inflammatory signaling in cell and mouse models of ALI. RAW264.7 macrophages were stimulated wi...

[Xuebijing Injection ameliorates sepsis-associated acute respiratory distress syndrome in mice by upregulating phospholipid transfer protein to regulate macrophage JNK/c-JUN pathway].

CREG1 mitigates sepsis-induced acute lung injury by mediating macrophage polarization via AMPK/NF-κB signaling.

BACKGROUND Sepsis-induced acute lung injury (ALI) is a severe respiratory disease that usually progresses to acute respiratory distress syndrome (ARDS). Cellular repressor of E1A-stimulated genes 1 (CREG1), a secreted glycoprotein, participates in tissue homeostasis, influences inflammation, and improves cardiovascular...

Madecassic acid attenuates sepsis-associated acute lung injury by regulating the PI3K/AKT/mTOR pathway to mediate anti-inflammatory, antioxidant and anti-apoptotic effects.

BACKGROUND Sepsis-induced acute lung injury (ALI) is a critical illness with a high mortality rate. Madecassic acid (MA), a pentacyclic triterpenoid extracted from Centella asiatica, exhibits multiple biological activities, but its role in sepsis-associated ALI remains poorly elucidated. OBJECTIVES The aim of this st...

β-Hydroxybutyrate induces microglial M2 polarization by inhibiting the NF-κB/NLRP3 pathway to ameliorate cerebral ischemia–reperfusion injury

Elevated endogenous BHB under obese conditions exerts neuroprotective effects against CIRI, and exogenous BHB can mimic this effect.