It is shown that the mouth is a reservoir for fungal Th17 cells that adopt pathogenic signatures in the gut during Crohn's disease.
Abstract
Candida albicans induces Th17 cells, but their origins remain unresolved. In this issue of Immunity, Martini et al. show that the mouth is a reservoir for fungal Th17 cells that adopt pathogenic signatures in the gut during Crohn's disease.
In this issue of Cell, Howard et al. reveal how the milk glycoprotein osteopontin shapes the neonatal microbiome to regulate hematopoiesis, promoting dendritic cell development and protection from severe respiratory infection. These findings uncover a maternal milk-microbiota pathway linking early-life nutrition to imm...
The resilience of the emerging fungal pathogen Candida auris poses a significant challenge to public health. In a recent study examining how this pathogen navigates changing host environments, Tedja et al. show that sensing nutrient availability differences between body sites is key to controlling immune evasion.
Ananya Dash, Christopher N. LaRock· Communications Biology· 0 citations
Ringham et al.1 identify CHL1+CXCL9+ cancer-associated fibroblasts at lung tumor margins that recruit suppressive CXCR3+ regulatory T cells, revealing how stromal chemokine gradients can promote immune evasion. Viewed alongside immune-stimulatory CCL19+ fibroblastic reticular cells, these findings suggest that immune-i...
L. Onder, Hung-Wei Cheng, B. Ludewig· Developmental Cell· 0 citations
A microbiota-orchestrated stem-like lymphoid niche in which CD70+ ILC2s sustain progenitor exhausted T cells is uncovered, and its findings redefine the functional organization underlying TLS-associated antitumor immunity.
