RIFM at 60: Six Decades of Advancing Fragrance Safety Through Research, Risk Assessment, and Scientific Innovation.

RIFM 60th Anniversary Special Issue: Toxicological Impact of RIFM Science Throughout the Years.

For six decades, the Research Institute for Fragrance Materials (RIFM) has helped shape the evolution of human and environmental toxicology by advancing science-based approaches for evaluating the safety of fragrance ingredients. This perspective reviews RIFM's major scientific contributions and their broader influence...

Strategic Application of New Approach Methodologies (NAMs) in Fragrance Ingredient Safety Assessment: Integration of In Vitro, In Silico, and Exposure-Based Approaches in RIFM Evaluations.

New Approach Methodologies (NAMs) are transforming toxicological risk assessment by providing human-relevant, non-animal approaches for hazard identification, exposure assessment, and safety evaluation. This manuscript presents an overview of the Research Institute for Fragrance Materials (RIFM) New Approach Methodolog...

RISK ASSESSMENT FOR FOOD SAFETY USING THE RISK MATRIX METHOD

Food safety incidents pose a serious threat to public health, and the food safety management system requires a scientifically grounded risk assessment toolkit. The aim of the study is to assess food safety risks across five aspects – food product categories, regions of Ukraine, entities involved in incidents, causes, a...

Progress in China’s Food Safety Standards for Physical and Chemical Testing Methods Over the Past Decade

Case Studies on the Safety Assessment Strategy for Botanical Extracts in Cosmetic Products.

N-NITROSAMINE IMPURITIES IN PHARMACEUTICALS: FORMATION PATHWAYS, TOXICOLOGICAL CONCERNS, REGULATORY APPROACHES AND RISK MITIGATION STRATEGIES

Background: N-nitrosamine impurities represent an important pharmaceutical quality and patient safety concern because several members of this chemical class exhibit mutagenic and carcinogenic potential. Objective: To synthesize scientific and regulatory evidence concerning their formation, toxicological assessment, an...