Oct 2026· Nanoscale· Vol 18, pp. 22979-23003· 0 citations
Medicine
TL;DR
This review systematically summarizes recent progress in biomaterial-based CNS repair, focusing on three core strategies: physical remodeling of the neural structure, targeted drug delivery systems for biochemical regulation, and cellular intervention.
Abstract
Effective repair of central nervous system (CNS) injuries remains highly challenging due to several formidable barriers, including severe structural disruption, hostile microenvironments, and limited intrinsic regenerative capacity. In response, biomaterials incorporated with therapeutic agents provide advanced interventional strategies for neural regeneration. This review systematically summarizes recent progress in biomaterial-based CNS repair, focusing on three core strategies: physical remodeling of the neural structure, targeted drug delivery systems for biochemical regulation, and cellular intervention. Furthermore, we critically analyze the manufacturing and regulatory bottlenecks currently impeding clinical translation. Finally, we propose the integration of neural organoids and brain-computer interface (BCI) technologies as a promising trajectory for next-generation intelligent neural repair materials.
Central and peripheral nervous system injuries represent major causes of neurological disability worldwide, yet current treatment methods are limited by issues including donor site morbidity, regenerative capacity, and tissue availability. Engineered biomaterials are being investigated as alternative strategies for neu...
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Central and peripheral nerve injuries can lead to permanent paralysis and organ dysfunction. With current methods, the return to previous quality of life after treatment of nerve damage is quite low. Complete recovery is not observed, and patients' mobility may continue to deteriorate even after treatment. Peripheral n...
Central nervous system (CNS) injuries, including traumatic brain injury, spinal cord injury, and stroke, are associated with high rates of disability and mortality. Challenges such as the obstruction of drug delivery by biological barriers, disrupted neuronal energy metabolism, complex microenvironments, and difficul...
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