Rutin exhibits multi-target anti-arthritic potential supported by both traditional use and modern pharmacological evidence, and its ability to modulate key inflammatory and oxidative pathways highlights its potential as a phytopharmaceutical candidate for arthritis management.
The findings underscore the promise of Fabaceae plants as valuable natural sources for developing safe and effective anti-arthritic agents, war-ranting further pharmacological and clinical investigations to establish their efficacy and safety profiles.
Sukanya Vijayan, Thirumal Margesan· Current Drug Therapy· 0 citations
This work supports the development of plant-based substitutes for existing medications by integrating contemporary molecular insights with traditional ethnopharmacological expertise, highlighting the therapeutic potential of phytochemicals for treating pain and inflammation-associated illnesses.
Ashutosh Mohanty, G. Pattnaik, J. Dash· Mini-Reviews in Medical Chem...· 0 citations
Rutin exhibits promising anti-inflammatory and anti-allergic activities through multitarget modulation of inflammatory, oxidative stress, and immune pathways, and limitations such as poor bioavailability, variability among experimental studies, and limited clinical validation remain significant challenges.
R. Mishra, J. K. Gupta, Vinay Jain· Anti-Inflammatory & Anti-All...· 0 citations
Diverse activities of rutin suggest that rutin may have potential in the prevention and management of oxidative stress-related and inflammatory disorders, however, further studies are required to establish its therapeutic efficacy, mechanisms, safety, and clinical applicability.
Peeyush Dixit, Anupama Rai, Gajendra Jayant et al.· International Journal of Res...· 0 citations
Overall, P. canescens shows promise as a multi-target source of anti-inflammatory bioactive compounds and some heterogeneity in the magnitude of cytokine modulation was observed, likely reflecting differences in extraction methods, doses, and experimental models.
Yunita Liana, S. Subandrate, M. Saleh et al.· Journal of Biota· 0 citations
Medicinal plants from Indian and Chinese systems offer potential as supportive agents in RA management and additional research should concentrate on the aspects of standardization, mechanistic studies and clinical validation to confirm their therapeutic benefits and their safe use alongside other traditional therapies.
