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Plasma Lipidome Is Dysregulated in Amyotrophic Lateral Sclerosis and Associated With Life‐Course Adiposity Polygenic Risk

Lin-Jing Zhang Le-Yuan Zhang Yong-Ping Zheng Zhen-Huang Zhuang Lu Tang Wei Zheng Kai-Lin Xia S. Ye Tie-Lun Yin Tao Huang Dong-Sheng Fan

Oct 2026 · Journal of Cachexia, Sarcopenia and Muscle · Vol 17 · 0 citations · 37 references

Medicine

TL;DR

This study aimed to investigate how genetic predisposition to adiposity might influence ALS through specific lipid metabolic pathways.

Abstract

Although both pre‐symptomatic adiposity and dysregulated lipid metabolism are implicated in amyotrophic lateral sclerosis (ALS), the mechanistic pathways linking adiposity to disease remain unclear. This study aimed to investigate how genetic predisposition to adiposity might influence ALS through specific lipid metabolic pathways.

DOI PubMed Semantic Scholar

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