Psychological stress in mice induces ageing-like HSC dysfunction through intestinal dysbiosis

Open access Aug 2026

Early-life stress-induced gut dysbiosis is ameliorated by nicotinamide treatment

Early life stress (ELS) in the form of adverse experiences in childhood results in multiple psycho-physiological pathologies during adulthood and accelerates aging. Such pathologies are recently observed to be alleviated upon nicotinamide treatment in a maternal separation model of ELS. We report a nicotinamide-driven...

Stuti Srivastav, Pratik R. Chaudhari, Shital Suryavanshi et al. · bioRxiv · 0 citations

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Editorial Open access Sep 2026

Stressed-out immune cells

The effects of stress hormones on the immune system are investigated using single-cell RNA sequencing to better understand how stress-regulated immunological signaling contributes to disease.

Jessica D. Rosarda · Cell Genomics · 0 citations

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Editorial Sep 2026

Microbiota-Gut-Brain Axis in Mood and Neuropsychiatric Disorders: Therapeutic Opportunities: Mini-thematic Issue.

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I. Bókkon, Noémi Császár-Nagy · Current Neuropharmacology · 0 citations

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Review Open access Aug 2026

Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk

Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction.

Yuanyuan Li, Jingwei Mao, Yiwen Deng et al. · Immunity, Inflammation and D... · 0 citations

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Open access Sep 2026

Indole-AhR signaling shapes emotional regulation.

Wang et al. identify a gut-brain pathway in which loss of the commensal bacterium Alistipes shahii reduces indole production, prevents hippocampal indole-AhR signaling, and drives anxiety and depression behaviors in patients and mouse models of irritable bowel syndrome.1.

Minjeong Kim, H. Vuong · Cell Reports · 0 citations

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Open access Jul 2026

Single‐Cell RNA Sequencing Reveals Disrupted Stromal–Epithelial Crosstalk Impairs Gut Barrier in Depression

Depressive disorder is commonly associated with gastrointestinal dysfunction, but the specific cellular and molecular alterations within the colonic mucosa remain poorly understood. The role of stromal–epithelial crosstalk in the colonic niche under depressive conditions is particularly unclear.

Xiao-Song Xu, Wan-Ning Zhang, Xu-Rui Hao et al. · Brain and Behavior · 0 citations

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