TIF1γ holds the line against regulatory T cell plasticity

Dysferlin promotes inflammatory macrophage responses and modulates Ca2+-dependent STAT1 signaling

This study links macrophage dysferlin to Ca²⁺-dependent STAT1-associated inflammatory responses and impaired myogenic differentiation in cellular models.

Old dog, new tricks: Astrocytes use the CD40 pathway to propagate neuroinflammation.

In addition to myeloid antigen-presenting cells (APCs), CD40 also induces APC potential in astrocytes during neuroinflammation.

TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment

Evidence is provided for a key role of TNFR1, as expressed by malignant cells, in orchestrating a pro-tumor immunosuppressive environment through secondary inflammatory mediators through secondary inflammatory mediators.

CARM1: an epigenetic brake on cDC1-mediated antitumor immunity.

The underlying mechanism of tumor microenvironment-induced dysfunction of conventional type 1 dendritic cells (cDC1) remains unclear. Zhang et al. identify transforming growth factor β-driven coactivator-associated arginine methyltransferase 1 (CARM1) as an epigenetic inhibitor of cDC1 cross-presentation. CARM1 is a ce...

Correction: Cellular repressor of E1A-stimulated genes 1 enhances skeletal muscle performance through the stimulation of muscle differentiation and Akt-mTOR signaling pathway activation

[This corrects the article DOI: 10.1371/journal.pone.0328485.].

Mind the Notch as AXL+ DC3s creep through the gap