Skip to content
Open access

Limited G-dependent residual infectivity of G gene–deleted vesicular stomatitis virus

Aug 2026 · Virus Research · Vol 372, pp. 199792 · 0 citations · 20 references
Medicine

TL;DR

Anti-VSV-G neutralization abolishes residual VSV-ΔG infection and G carryover control is critical for VSV-ΔG vector biosafety.

Abstract

Highlights • Residual VSV-G determines infectivity of VSV-ΔG vector particles.• Anti-VSV-G neutralization abolishes residual VSV-ΔG infection.• VSV-ΔG particles show limited passage-dependent infectivity.• G carryover control is critical for VSV-ΔG vector biosafety.

Read PDF

Similar papers

Open access Sep 2026

Genomic characterization of the attenuated human cytomegalovirus strain TR-VAC developed for subviral particle vaccine production

The complete genome sequence of the attenuated human cytomegalovirus strain TR-VAC, developed for subviral particle vaccine production, is reported, without large-scale structural rearrangements.

H. Schmidt, C. Hewel, Nicole Büscher et al. · 0 citations
Open access 2026

Linker-dependent performance of gH625–siRNA conjugates enables carrier-free brain delivery and prophylaxis against HSV-1 infection

Nectin-1 is a major entry receptor involved in HSV-1 infection of the brain, making its suppression before viral exposure a potential host-directed preventive strategy. siRNA can reversibly reduce Nectin-1 expression,...

Yi-Wan Geng, Jia-Min Zuo, Yu-Sheng Zhang et al. · 0 citations
Open access

Virus-Like Particles as a Nonviral CRISPR/Cas Editing Delivery Tool.

A protocol for generating VSV-G-pseudotyped VLPs that deliver CRISPR/Cas9 RNPs and their functional validation in surrogate cell lines is described and their functional validation in surrogate cell lines is validated.

Antonio Carusillo, A. Naseem, A. Cavazza · 0 citations
Open access Aug 2026

DENV-4 infection suppresses transcription of DNA repair genes

It is shown that DENV-4 infection induces significant DNA damage and suppresses the transcription of genes involved in DNA repair and select mutagenic translesion synthesis (TLS) polymerases, indicating that DENV-4-dependent pathobiology leaves durable biological “scars” that incrementally increase chronic disease risk...

Erica N Lamkin, Jessica Reich, Josh A. Victor et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.