[IGFBP-4 improves synovitis by reducing M1 polarization of macrophages via the Wnt/β-catenin pathway].

The IL-4/IL-4R/STAT6 signaling axis regulates macrophage efferocytosis in osteoarthritis

Depletion of PTGS1 Inhibits IL-1β-Induced Inflammatory Responses and Osteoblast Dysfunction in MC3T3-E1 Cells via the Wnt/β-Catenin Pathway

In vitro findings suggest that PTGS1 may modulate osteoblastic responses under inflammatory conditions; however, further validation is required before any conclusion regarding TMJ-OA can be drawn.

Inhibition of BMP–Smad1/5 signaling with DMH1 attenuates joint degeneration in a rat model of cuff tear arthropathy

Objective To characterize bone morphogenetic protein (BMP) signaling in cuff tear arthropathy (CTA) using a modified rat model (mCTA) and determine whether inhibition of DMH1-sensitive BMP type I receptor signaling attenuates CTA pathology. Design The rat mCTA model was generated by resection of the supraspinatus and i...

AGTR1 inhibits pyroptosis and inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes through the TGF-β pathway.

BACKGROUND Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease. The hyperactivation of fibroblast-like synoviocytes (FLS) is a major contributor to synovial hyperplasia and cartilage destruction, and FLS pyroptosis plays a pivotal role in RA pathogenesis. This study aimed to investigate the mechanism...

ameliorates CCl 4 -induced liver fibrosis in mice by inhibiting the NF-κ B pathway

Mechanisms underlying the inhibition of chondrocyte apoptosis and inflammatory cytokine expression in knee osteoarthritis by rehmannia glutinosa polysaccharides via PI3K/AKT pathway activation at different concentrations.

BACKGROUND Knee osteoarthritis (KOA) is a persistent articular disorder primarily defined by cartilage degradation and inflammatory response, where chondrocyte apoptosis serves as a critical pathological mechanism. OBJECTIVE This work aimed to investigate the effects of rehmannia glutinosa polysaccharides (RGP) on in...