It is demonstrated that viscoelastic PEG–alginate hydrogels enhance the stability, cellular uptake, and pro-angiogenic efficacy of MSC-derived exosomes while providing cytoprotective effects, highlighting their potential as an effective delivery platform for angiogenesis-mediated regenerative therapies.
This work establishes a new benchmark for high-performance regenerative therapies by successfully aligning advanced tissue engineering with circular economy principles and shows that the quality of exosomes is dictated by the architectural cues of the microenvironment rather than solely by production yield.
Guadalupe Estrella-Guisado, Victoria Pulido-Escribano, Begoña Ferrari et al.· International Journal of Bio...· 0 citations
It is demonstrated that skin organoid-derived exosomes in a hydrogel system synergistically promote wound healing through tissue-specific cues, offering a next-generation therapy for refractory wounds.
Tao Yang, Wen Zheng, Yue Li et al.· Materials Today Bio· 0 citations
In a rat full-thickness skin defect model, the combined Gel-Exo-NB and Gel-Exo-NB + US treatments achieved the highest wound-closure rate among all groups, with enhanced re-epithelialization, a reduced scar index, elevated CD31 and α-SMA expression, increased fibroblast proliferation, and increased blood vessel formati...
Elnaz Bagheri, Elahehsadat Aminyazdi, Sara Amel et al.· Biomedicine & pharmacotherap...· 0 citations
The article critically analyzes methods for exosome isolation, loading strategies into hydrogel matrices, and essential characterization techniques to ensure vesicle integrity and predict in vivo performance, and highlights the compelling therapeutic efficacy of this synergistic platform across diverse regenerative app...
Elaheh Esmaeili, Iman Rad, Saied Soflaei et al.· Journal of Polymers and the...· 0 citations
In both normal and diabetic murine full-thickness skin defect models, DEPL@E-SI significantly accelerated wound closure by promoting angiogenesis, inflammation resolution, and extracellular matrix remodeling, establishing DEPL@E-SI as a promising therapeutic platform with translational potential for skin tissue enginee...
Xiangyu Du, Danmei Li, Hongpu He et al.· Bioactive Materials· 0 citations
By integrating the regenerative potential of ADSCs lysate with this biocompatible, injectable hydrogel platform, this combined strategy circumvents the potential safety issues associated with live cell transplantation and offers a scalable, potential cell-free delivery strategy for myocardial repair-related application...
Ziwei Du, Qi Zhang, Qiuhua Wang et al.· Frontiers in Bioengineering...· 0 citations
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