A testable integrative model in which microvascular injury, blood-brain barrier disruption and neuroinflammation may contribute to persistent cognitive symptoms in PCS is outlined, as current data are largely cross-sectional and derive partly from in vitro work.
The conclusion that routine CSF abnormalities largely do not seem to reflect mechanisms specific to PCS is argued against routine CSF diagnostics as a source of disease-specific biomarkers in unselected PCS patients and support future studies focusing on alternative mechanisms underlying persistent neurological symptom...
D. Erhart, L. Balz, I. Giotaki et al.· medRxiv· 0 citations
Long COVID, a major post-acute infection syndrome (PAIS), characterized by prolonged or new-onset symptoms following acute COVID-19, critically affects patients' quality of life. Establishing easily measurable and objective biomarkers that reflect disease severity is essential for clinical management. This retrospectiv...
Rie Ono, Shin Takayama, Michiaki Abe et al.· Frontiers in Medicine· 0 citations
The available evidence supports a multifactorial pathophysiological model involving viral persistence, immune dysregulation, autoimmunity, endothelial dysfunction, dysautonomia, and mitochondrial impairment, which is a heterogeneous multisystem condition involving neurological, respiratory, cardiovascular, musculoskele...
A. Clemente, Isabel Cristina, Correa Correa et al.· 0 citations
The SARS-CoV-2 virus has infected approximately 778 million people worldwide since the pandemic. Patients who have survived coronavirus disease (COVID-19) may experience long-term symptoms related to cognitive deficits, mood changes, and depressive disorders. The mechanisms underlying the long-term effects of COVID-19...
Luiza Marek-Józefowicz, Alina Borkowska, B. Nedoszytko et al.· International Journal of Mol...· 0 citations
This study consists of an integrative literature review with an electronic search in the PubMed database, aiming to gather information and data established by the scientific community regarding the pathogenesis and development of neuropsychiatric sequelae in Post-COVID-19 Syndrome.
Gabrielle Pereira Damasceno, Sarah Romenia Souza Martins, C. D. de Cordova et al.· Revista de Estudos Interdisc...· 0 citations
PAS and PACVS exhibit substantial clinical and immunological overlap, including GPCR-directed autoreactivity and altered receptor-reactive T-cell responses, which suggest overlapping pathophysiological mechanisms.
J. Dinser, M. Anft, L. Wiemers et al.· medRxiv· 0 citations
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