The principles that shape cardiovascular ASO candidate development are discussed, with emphasis on mechanism selection, chemical design, and exposure feasibility, and sequence optimization with exposure-informed target qualification and therapeutic-index engineering throughout ASO candidate selection.
D. Park, A. Bühler, Christian Schöllhorn et al.· Expert Opinion on Drug Disco...· 0 citations
Emerging biomarkers are fundamental for the transition to precision medicine in IBD, aiming to enhance pathogenesis understanding, personalize therapies, and improve patient quality of life, establishing pathways for more effective, individualized management approaches.
Matheus Querino da Silva, João Daniel de Souza Menezes, José Luis Esteves Francisco et al.· PLoS ONE· 0 citations
Across April and May 2026, the nucleic acid therapeutics field saw broad regulatory momentum, continued clinical advancement, and significant manufacturing investment, with AI-driven drug discovery also advanced.
This paper summarizes recent advances in biosensor technologies, AI-derived biomarkers, and predictive frameworks used to help identify patients more accurately, monitor their progress continuously, and receive optimized therapies.
S. Bukke, Chandrashekar Thalluri, Mallikarjun Vasam et al.· Personalized Medicine· 0 citations
The integration of computational prediction with programmable genome and RNA engineering may support more precise, adaptable, and clinically translatable mRNA therapeutics.
Haixing Shi, Shengbin Liu, Dan-Ling Dai et al.· MedComm – Biomaterials and A...· 0 citations
A new method for surgically removing training examples from a model reveals that as datasets grow, the link between what a model learns and what it produces dissolves.
