2026· International review of neurobiology· Vol 188, pp.
273-298
· 0 citations
Medicine
TL;DR
The chapter provides in-depth information on the role of HDAC inhibitors, which hold significant potential as disease-modifying agents in the treatment of Alzheimer's disease and explores various challenges such as off-target effects, restricted isoform specificity, and inadequate blood-brain barrier permeability.
Overall, epigenetic modulators present a promising therapeutic approach for neurodegeneration, and continued research integrating various assays like DNA methylation analysis, histone modification analysis, non-coding RNA analysis, neuroinflammation analysis, and functional and behavioral assays in AD models is signifi...
Debojyoti Halder, Denish Prajapati, Tonmoy Banerjee et al.· Methods in Enzymology· 0 citations
Pharmacological inhibition of HDAC activity has been shown to restore histone acetylation levels, enhance the expression of neuroprotective genes, and improve synaptic plasticity in various experimental models.
Padmanabh Singh, M. K. Thakur· Methods in Enzymology· 0 citations
This review examines the molecular and cellular mechanisms through which neuroinflammation contributes to the progression of AD, with particular emphasis on microglial activation, TREM2 and soluble TREM2 (sTREM2) signaling, NLRP3 inflammasome activation, astrocyte–microglia interactions, and blood–brain barrier dysfunc...
Shreyansh Goswami· International Journal For Mu...· 0 citations
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral disturbance, largely associated with amyloid-β accumulation, tau protein pathology, synaptic dysfunction, oxidative stress and neuroinflammation. Previous research emphasizes the critical...
A. Shaheen, Mou-Sa A. Mai, Merhan O. Hindam et al.· Frontiers in Pharmacology· 2 citations
Alzheimer’s Disease (AD) is a neurodegenerative disorder with
progressive cognitive decline, β-amyloid plaques, neurofibrillary tangles, oxidative stress,
and neuroinflammatory responses. So far, the pathogenesis of AD has been explained by
the cholinergic hypothesis, amyloid cascade hypothesis, and tau protein dys...
Lalit Parihar, A. Singh, Sanjar Alam· Current Pharmacogenomics and...· 0 citations
