Biological Embedding of Adverse Childhood Experiences: Neurobiological and Immune Mechanisms Linking Early-Life Stress to Addiction Vulnerability.

Beyond the brain circuit: a biopsychosocial integrative review of addiction neuroscience, epigenetic mechanisms, and multidisciplinary treatment

A central argument of this review is that addiction is not solely a brain circuit disorder but also a disorder of social connection and meaning, in which neuromodulation serves as one component of a comprehensive approach that targets the neurobiological, psychological, and relational dimensions of addiction simultaneo...

672. Adolescence at the crossroads of prenatal stress: unraveling neurobiological vulnerabilities and the early protective role of a ketogenic diet

Abstract Background Stress is a major etiological factor in the development of mental disorders, particularly when exposure occurs during sensitive developmental windows. Prenatal stress (PNS) has been shown to induce long-lasting behavioral and neurobiological alterations that emerge during adolescence and persist int...

Molecular and Cellular Mechanisms Linking Mood Disorders, HPA Axis Dysregulation, and Neurocognitive Inflammation to Perioperative Neurocognitive Disorders

Patients with preexisting mood disorders may enter surgery in a biologically sensitized neuroimmune state, lowering the threshold for exaggerated neuroinflammatory responses and postoperative cognitive dysfunction, according to a review of convergent pathophysiologic pathways.

Associative Learning and Adverse Childhood Experiences: A Multi-System Protocol.

Adverse childhood experiences (ACEs) are established transdiagnostic risk factors for adult anxiety and depression, yet the neurocognitive mechanisms linking early adversity to symptoms remain unclear within a unified framework. This protocol presents an integrated, multi-system experimental battery that captures threa...

687. Unraveling the suicide-inflammation axis and the moderating role of early life stress insights from polygenic risk score analyses

Abstract Background Elucidating the biological underpinnings of suicidal behavior and identifying reliable biomarkers remains a major challenge in suicide research. Equally critical is delineating the role of environmental factors, particularly early-life adversity but also acute and recent stressors in modulating suic...

Stress and Cancer from an Integrative Psychoneuroimmunology Perspective: Neurobiological Mechanisms and Clinical Implications.