TL;DR
Computational analyses suggest a potential relationship between KIFC1-associated malignant states and tumor microenvironmental signaling, supporting its value as a prognostic biomarker and potential therapeutic target.
Highlights • Integrative single-cell and spatial transcriptomic analyses identify LMX1B as a previously unrecognized tumor suppressor in renal cell carcinoma.• LMX1B-associated epithelial cells function as central signaling hubs within the tumor microenvironment, engaging in spatially organized bidirectional communicat...
This study identified UBE2C+ proliferative tumor cells as a functionally relevant malignant subpopulation in SCLC and links this state to immune-stromal communication networks within the tumor microenvironment and provides a systems-level framework for investigating the cancer-immunity regulome in SCLC.
Integrative single-cell RNA sequencing analysis of publicly available datasets from non-small cell lung cancer and breast cancer is performed to systematically map transcriptional heterogeneity and regulatory networks within the TME, providing a systems-level framework of TME organization.
Introduction Prostate cancer recurrence reflects molecular and histological heterogeneity, yet the cellular states harboring recurrence-associated signals and their potential environmental modifiers remain incompletely understood. Methods We integrated single-cell RNA sequencing, bulk transcriptomes with recurrence ann...
IDH-mutant gliomas show variable clinical behavior that may reflect transcriptional programs organized within tumor tissue. We evaluated two curated expression scores: a differentiation-loss/Stem-NPC score (Axis1) and a mesenchymal–hypoxia score (Axis2). Public single-cell RNA-sequencing data were used to characterize...
Background Small-cell lung cancer (SCLC) is characterized by pervasive chromosomal instability (CIN) and remains largely refractory to targeted therapies. KIF18A, a motor protein that regulates chromosome alignment during mitosis, has emerged as a selective dependency in CIN-high tumors. Whether this dependency extends...
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