SUMOylation of HSF1 orchestrates transcriptional and splicing programs during the proteotoxic stress response

S. Mueller Upayan Patra Svenja Kuska Thorsten Mosler GU Frankfurt T. Makarov Urbi Mukhopadhyay C. Münch U. Keller M. Müller-McNicoll M. Wirth

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TL;DR

In cells recovering from proteotoxic stress, inhibition of SUMO conjugation led to sustained activation of Heat Shock Factor 1 (HSF1) and SUMOylation of HSF1 as a central regulatory node for restoration of proteostasis, highlighting the critical role of SUMO signaling in regulating the dynamics of a molecular condensate.

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