VU Research Portal A four-dimensional probabilistic atlas of the human brain

a voxel-based morphometric study of age-and sex-related changes in white matter volume in the normal aging brain

Global and Medial Temporal MRI Morphometry in Alzheimer’s Disease and Cognitively Normal Adults: A Retrospective Association Study

Background/Objectives: Alzheimer’s disease is one of the most prevalent forms of dementia and is accompanied by progressive anatomical changes within the brain. However, large-scale analyses that compare global and local anatomical differences across age, sex, diagnosis, and repeated scans remain limited. Methods: We c...

City Research

Comparison of subject-to-template registration schemes using CT and MR radiotherapy images with brain lesions

Introduction Voxel-based analyses have been used more widely in radiotherapy in recent years. The purpose of this study is to compare eight different methods of registering images on to a template space for such analyses. A novel way, using both CT and MR data, is proposed. Methods CT and MR brain images from 85 partic...

Algebraic Connectivity Reveals Modulated High-Order Functional Networks in Alzheimer's Disease.

A hypergraph was employed to model high-order functional relations across brain regions, introducing algebraic connectivity ($a(\mathcal {G})$) for estimating the hyperedge weights, suggesting that $a(\mathcal {G})$ can be an effective approach for extracting the hyperedge weights, including important functional inform...

External Validation of a Mathematical Model of Brain Health

Background Understanding the mechanisms underlying brain aging and age-related pathological changes is essential for advancing brain health research. Our group previously developed a mechanistic mathematical model of healthy brain, Chamberland et al. (2024) that integrates key biological processes involved in normal ag...