Design of a bioactive nickel(II) complex based on a hydrazone Schiff base ligand: Synthesis, structural characterization and antimicrobial investigations
TL;DR
The nickel complex exhibited significantly enhanced antibacterial activity compared to the free ligand, an improvement that may be attributed to the chelation effect and the increased lipophilicity of the complex.
Abstract
A novel hydrazone Schiff base ligand (H3L) and its nickel(II) complex were synthesized and fully characterized using a range of spectroscopic techniques. The antibacterial activities of both compounds were evaluated against Gram-positive and Gram-negative bacterial strains by means of the agar diffusion method, minimum inhibitory concentration (MIC) assays, and minimum bactericidal concentration (MBC) assays. The nickel complex exhibited significantly enhanced antibacterial activity compared to the free ligand, an improvement that may be attributed to the chelation effect and the increased lipophilicity of the complex. The present work aimed to synthesize a novel hydrazone Schiff base ligand and its nickel(II) complex, characterize their structures, and evaluate their antibacterial activities against selected pathogenic bacterial strains. The ligand (H3L) crystallizes in the monoclinic system in the space group C2/c, with unit cell parameters a = 21.0113(2) Å, b = 6.9353(4) Å, c = 21.3996(9) Å, α = 90°, β = 104.202(2)°, γ = 90°.