The present study proposes the possibility of PRMT8 as a cancer biomarker, based on the high level of PRMT8 expression in various types of cancer, particularly in tissues that would not normally be expected to express PRMT8, and on the correlation of PRMT8 and patient lifespan in several cancer types.
An association of STK35L1 and EGFR in BC is reported, highlighting STK35L1 as a potential prognostic biomarker and therapeutic target and suggesting that EGFR-STAT3 signaling may regulate STK35L1 and EGFR expression.
Saloni Bage, Arpana Yadav, Kritika Gaur et al.· Functional & Integrative Gen...· 0 citations
This study found that LINC02257 and LINC00659 are upregulated in BC and are associated with malignancy-related genes and patient survival, suggesting their potential as therapeutic targets and prognostic biomarkers.
Fatemeh Badzohre, Azin Azadfekr, Farnoosh Akbari et al.· Current Genetic Medicine Rep...· 0 citations
Functional studies demonstrated that IFI35 knockdown effectively suppressed BRCA cell proliferation, migration, and invasion, while promoting apoptosis, and is a potential therapeutic target for BRCA.
Yu-Dong Mu, Tao Zhang, Lin He et al.· Journal of Surgical Research· 0 citations
Background: LIM and calponin homology domain-containing protein 1 (LIMCH1) regulates myosin stress fiber assembly and cell motility and is involved in carcinogenesis. However, its role in ovarian cancer remains poorly characterized. In this study, LIMCH1 was identified as a candidate tumor suppressor gene through analy...
Peng-Feng Zhu, Xiang Fan, Yi-Fei Wang et al.· Clinical and Experimental Ob...· 0 citations
TGF-β receptor 1 (TGFBR1) is a key component of TGF-β signaling and has been implicated in tumor progression. However, its expression patterns, prognostic relevance and associated molecular contexts vary among malignancies and remain incompletely characterized within a consistent pan-cancer framework. In the present st...
Xia Zhao, Lu-Fan Shen, Zhi-Yuan Gong et al.· Oncology Letters· 0 citations
Tetratricopeptide repeat domain protein 39B (TTC39B) is a lipid metabolism–related gene recently implicated in cholesterol regulation. However, its clinical and biological relevance in human cancers remains undefined.
Based on multi-omics data from the Cancer Genome Atlas (TCGA) pan-cancer dataset represen...
Hui-Juan Yi, Yan Wang, Chen-Hao Zhao et al.· BMC Medical Genomics· 0 citations
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