Yangyin Shengji Powder inhibits inflammation and promotes the wound-healing in oral ulcers through regulating SIRT1/NF-κB p65 signaling pathway.

Shengji Yuhong Ointment accelerates diabetic wound healing by suppressing AGEs/RAGE-related inflammation and restoring HIF-1α/VEGF-mediated angiogenesis.

ETHNOPHARMACOLOGICAL RELEVANCE Shengji Yuhong Ointment (SJYHO) is a classic external formula in traditional Chinese medicine surgery, which was first recorded in Wai Ke Zheng Zong. It is commonly used for conditions such as chronic non-healing sores and ulcers, failure of necrotic tissue to slough off, poor granulation...

Lipid Mediators Derived from Docosahexaenoic Acid Alleviate Periodontal Inflammation and Alveolar Bone Loss in Periodontitis Associated with Suppression of the NF-κB and STAT3 Signaling Pathways

Background: Lipid mediators (LM), comprising 17S-hydroxy-docosahexaenoic acid, resolvin D5, and protectin DX in a ratio of 3:47:50, were naturally generated from docosahexaenoic acid by soybean lipoxygenase and exhibit potent anti-inflammatory activities. However, their therapeutic potential in periodontitis (PD) remai...

Dehydrocorydaline Accelerates Palatal Wound Healing in Mice Through Suppression of the p38 MAPK/CCL2 Axis and Macrophage Chemotaxis: A Preliminary Study

Investigating whether DHC accelerates palatal wound healing and to elucidate the role of the p38 mitogen-activated protein kinase (MAPK)/CCL2 signaling axis in DHC-mediated regulation of macrophage chemotaxis demonstrated that DHC accelerated palatal wound healing 1.6-fold in mice.

Anti-inflammatory, wound healing, and hepatoprotective effects of Acampe papillosa (Lindl.) Lindl. seed in wistar rats: insights from biochemical, histopathological, and in silico investigations

Securidaca inappendiculata Extract Mitigates Joint Damage in Collagen‐Induced Arthritis Rats Through Modulation of the SIRT1/HIF‐1α/Glycolysis Pathway

Mechanistic studies revealed that XAN attenuates inflammation by regulating the SIRT1/HIF‐1α/glycolysis signaling axis in macrophages, indicating that its anti‐inflammatory activity involves modulation of cellular energy metabolism.

Asiatic acid attenuates indomethacin-induced gastric ulcer in rats: Association with reduced IFN-γ/JAK-1/STAT3 signaling.

Gastric ulceration is a common dose-limiting adverse effect associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs). Asiatic acid (AA) is a naturally occurring pentacyclic triterpenoid that has been reported to possess antioxidant, anti-inflammatory, and healing properties. The present study investiga...