Jul 2026· Occupational Hygiene and Medical Ecology· pp. 63-79· 0 citations· 16 references
TL;DR
Criteria for establishing occupational causality, latency periods, oxidetive stress, immune disturbances and molecular biomarkers, and the need for a national occupational cancer registry and risk-based surveillance of workers exposed to occupational carcinogens is substantiated.
Abstract
Occupational cancer remains one of the most important challenges in occupational health and public health. This review summarizes current evidence on the global burden of occupational malignancies, major workplace carcinogens, occupational respiratory cancer and international registration systems. Particular attention is paid to mining workers and the under-recognition of occupational cancer in Kazakhstan. The article discusses criteria for establishing occupational causality, latency periods, oxidetive stress, immune disturbances and molecular biomarkers. The need for a national occupational cancer registry and risk-based surveillance of workers exposed to occupational carcinogens is substantiated.
Cancer risk is predominantly shaped by environmental exposures interacting with genetic susceptibility, yet modifiable non-genetic determinants remain insufficiently characterised. The human exposome framework promotes a comprehensive, life-course approach to studying chemical, biological, and physical exposures alongs...
Smokeless tobacco (SLT) is a major global health risk due to its established genotoxic and carcinogenic effects. This brief communication summarizes the most significant and contemporary molecular mechanisms, including oxidative stress, nitrosamine-driven DNA adduct formation, and heavy-metal-mediated repair inhibiti...
Ashek Elahi Noor, Hsiao-Ling Huang· Journal of Cancer Research a...· 0 citations
Occupational exposure to hazardous chemicals remains a major public health challenge, particularly in developing countries where regulatory enforcement and surveillance systems are limited. This review synthesizes recent advances in the application of biomarkers for assessing occupational chemical exposure and related...
C. Polyong, Thawatchai Eksanti, Pichitra Patipat et al.· Asian Health, Science and Te...· 0 citations
Longitudinal studies with standardized exposure characterization and harmonized diagnostic protocols are needed to establish causality and improve risk assessment in occupational settings, with considerable heterogeneity in exposure assessment and outcome definitions.
Ali Dehghani, Sylvia H. J. Jochems, Yvette Christopher-de Vries et al.· Particle and Fibre Toxicolog...· 0 citations
The International Agency for Research on Cancer (IARC) was the first public health agency to conclude that an agent – in this case, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) – could be carcinogenic based on associations with all cancers combined, even though there were no consistent associations with any particular ca...
J. Goodman, S. Marchitti, Nicole S. Olgun et al.· Global Epidemiology· 0 citations
Aromatic amines are environmental and occupational pollutants found in industrial chemicals, tobacco smoke, hair dyes, and azo-dye-containing textiles. Epidemiological studies confirm that occupational settings and tobacco smoking are the primary sources of exposure, with inhalation and dermal absorption being the majo...
Shu-Xin Li, Yue-Qiu Zhang, Tie Mao et al.· Frontiers in Cell and Develo...· 0 citations
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