Streptomyces griseoincarnatus AR2 from the cold desert as a biofactory for secondary metabolites with multifaceted bioactivities, confirmed by in vitro and in silico approaches

Antibacterial phenolic compounds target GMPS from the endophytic Chaetomium grande-JPT2.

This is the first report on GMPS inhibition by phenolic compounds, and the binding interaction between 11 and GMPS was primarily stabilised by two hydrogen bonds formed between the hydroxyl group in 11 and amino acid residues in GMPS.

Isolation and characterization of Shouchella clausii MJ1G0B, a novel halotolerant bacterium from Madura salt ponds: a putative Valenciaxanthin-like xanthophyll with antioxidant and antibacterial activities

Endophytic Paenibacillus lactis PEL6 from Mitrephora heyneana as a Source of Anti-Staphylococcus aureus Metabolites: In Vitro and In Silico Evaluation

Overall, this study identifies P. lactis PEL6 as a promising endophytic source of anti-S.

GC-MS identification of a lacthydrazide-class siderophore produced by Streptomyces sp. VITGV100: its antimicrobial activity and molecular docking

The bacterial genus Streptomyces comprises well-known producers of bioactive compounds, mainly antibiotics. Specifically, the strain Streptomyces sp. VITGV100 shows promise as a potent antimicrobial source. This study investigates the activation of cryptic biosynthetic genes within this strain through chemical elic...

7α-Hydroxypaxilline, a Natural Product Isolated from Mangrove Endophytic Fungi, Inhibits Protein Translation in Vibrio alginolyticus

Vibrio alginolyticus, a prevalent marine Gram-negative pathogenic bacterium, can cause vibriosis in aquaculture and pose potential threats to human health. The excessive abuse of antibiotics has aggravated the multidrug resistance of bacteria, driving researchers to explore natural antibacterial substances from mangrov...

Capsimycin derivatives from Streptomyces sp. PH9007 as α‑glucosidase inhibitors and insights into their biosynthetic gene cluster

The increasing number of individuals with diabetes mellitus (DM) highlights the need to develop new diabetes medications. Polycyclic tetramate macrolactams (PTMs), characterized by a macrocyclic lactam containing an integrated tetramic acid ring, constitute an expanding group of extensively dispersed natural comp...