2026· [Rinsho ketsueki] The Japanese journal of clinical hematology· Vol 67 7, pp.
794-801
· 0 citations
Medicine
TL;DR
Research showing that patient and donor genetic polymorphisms (SNPs) can predict transplant complications such as GVHD, and that reduced gut microbiota diversity, as detected by metagenomic analysis, impacts GVHD severity and survival are discussed.
This review synthesizes contemporary breakthroughs in HSCT biology, technology, and clinical application, critically examines unresolved barriers, and highlights future directions, including Artificial Intelligence (AI)-driven predictive analytics, universal donor platforms, and equitable global access strategies.
M. Abah, Ovwigho Ugbede, Oghenetejiri C et al.· DS Reviews of Research in Li...· 0 citations
The study showed that the re-emergence of recipient-derived clones, particularly oncogenic DNMT3A mutations, frequently preceded graft failure or disease relapse, and suggested that comprehensive molecular screening of donors and longitudinal molecular monitoring of recipients may be essential to optimize transplant ou...
Valentina Giudice, Denise Morini, M. Langella et al.· International Journal of Mol...· 0 citations
This narrative review synthesizes current indications for autologous (auto-HSCT) and allogeneic (allo-HSCT) transplantations in adults, and flags areas of persistent controversy where randomized data are still maturing.
A. Duminuco, G. Palumbo, Eleonora Avella et al.· Journal of Clinical Medicine· 0 citations
A five-axis framework to guide referral, treatment selection, and survivorship planning is proposed to guide referral, treatment selection, and survivorship planning for pediatric hematopoietic cell transplantation for nonmalignant disorders.
Eman M. Elsabbagh, Ahmed A. Shawky, Christopher C. Dvorak· Pediatric annals· 1 citation
BACKGROUND
Genomic characteristics play a critical role in the diagnosis, prognosis, and treatment of hematologic malignancies such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Germline profiling of MDS/AML patients who are candidates for allogeneic hematopoietic stem cell transplant (allo-HSCT)...
Allison S. Williams, A. Desalvo, Gabriela Sanchez-Petitto et al.· Transplantation and Cellular...· 0 citations
PURPOSE OF REVIEW
Relapse remains the leading cause of treatment failure after allogeneic hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), and outcomes after relapse are poor. This review summarizes and critically appraises current evidence for post-HCT main...
Nihar Desai, I. Pašić· Current opinion in hematolog...· 1 citation
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