Sustainable UHPLC-MS/MS assay for ultra-sensitive simultaneous quantification of amoxicillin and flucloxacillin with application to a bioequivalence study.
Aug 2026· Analytical and Bioanalytical Chemistry· 0 citations· 43 references
Medicine
TL;DR
The developed UHPLC-MS/MS method was successfully applied in a bioequivalence study involving 33 healthy volunteers following oral administration of a single 5 mL dose of Flucamox® 250 mg, enabling comprehensive pharmacokinetic evaluation while promoting sustainable and resource-efficient analytical practices.
Ibuprofen is a nonsteroidal anti-inflammatory drug first launched in England in 1969, yet its pharmacokinetic profile in healthy Chinese volunteers remains insufficiently characterized. In this study, a sensitive and reliable ultra-high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method wa...
Mei-Ah Yang, Kui He, Yu-Jie Mo et al.· Acta Chromatographica· 0 citations
Phloroglucinol is a smooth muscle relaxant widely used for the symptomatic treatment of gastrointestinal, biliary, and genitourinary spasms. A sensitive, rapid, and robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method incorporating a stable isotope-labeled internal standard (SIL-IS, phloroglucinol-13...
Qi-Qin Sun, Xiang-Hong Li, Yun-Jie Dong et al.· Journal of chromatography. B...· 0 citations
A sensitive and validated liquid chromatography-tandem mass spectrometry method was developed for the simultaneous quantification of the anti-COVID-19 agents molnupiravir, its active metabolite N-hydroxycytidine (NHC), and baricitinib in human plasma, and met the acceptance criteria.
Fatma H. Ghazy, Ramzia I. El-Bagary, Samar H. Fahim et al.· Bioanalysis· 0 citations
Objective: Nifurtimox is a type of nitrofuran derivative employed for treating sleeping sickness as well as Chagas disease. The aim is to develop and validate a precise and specific liquid chromatography mass spectrometric technique for the estimation of Nifurtimox in human plasma.Material and Method: Chromatographic s...
J. K. Bokam, Jagadeesh Adari, Ch Rama Naidu Gorripati et al.· Ankara Universitesi Eczacili...· 0 citations
Objective: The primary objective of the present research was to develop an accurate liquid chromatography and tandem mass spectrometry (LC-MS/MS) technique utilizing electrospray ionization for the quantification of Lurbinectedin in biological matrices.
Methods: The components were isolated using chromatographic techni...
P. Sankar, Naresh Panigrahi· International Journal of App...· 0 citations
