AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
The findings suggest that CAFs-derived CCL11 may represent a potential therapeutic target for PCa, largely through regulating CDK5 expression.
Cancer-associated fibroblasts (CAFs) represent a pivotal component of the breast cancer microenvironment. In a paracrine model, CAFs secreted the chemokine CXCL12 (SDF-1α), which bound to CXCR4 and activated the PI3K/AKT and MAPK signaling pathways, stimulating their migration and invasion. TGF-β1 induces myofibrob...
CAV1 is identified as a fibroblast-associated gene linked to stemness- and ferroptosis-related signatures and promoting bladder cancer progression by activating the LIF-STAT3 signaling axis.
This study delineates a novel CAF-driven immunosuppressive pathway in HCC, where CD147+ CAFs enhance tumor cell PD-L1 expression and susceptibility to immune checkpoint blockade via a TIMP2/MMP2/IL-6 axis.
A VEGFA-associated functional CAF state promotes gastric cancer organoid growth and chemoresistance through paracrine signaling, highlighting the CAF-VEGFA axis as a potential therapeutic target.
Pancreatic ductal adenocarcinoma (PDAC) remains highly refractory to chemoimmunotherapy due in large part to its dense, immunosuppressive stroma. Cancer-associated fibroblasts (CAFs), the dominant stromal cell population, promote tumor progression through inflammatory signaling, aligned collagen-rich extracellula...
Serving as a highly prevalent malignant tumor, lung adenocarcinoma (LUAD) is frequently associated with the establishment of an immunosuppressive tumor microenvironment during its initiation and progression, where M2-polarized macrophages exert pivotal effects. NCAPD3 acts as an oncogenic driver in multiple tumors; how...
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