OPN levels are rapidly increased in the bronchoalveolar space during K. pneumoniae pneumonia, where OPN serves a chemotactic function towards neutrophils, thereby facilitating an effective innate immune response.
Pneumonia continues to represent a significant global health concern, characterized by substantial morbidity and mortality despite advancements in modern medicine.
This respiratory infection remains a leading cause of hospitalization and death worldwide, particularly in developing nations. This study inves...
Mycoplasma pneumoniae pneumonia (MPP) can cause serious extrapulmonary complications, including life-threatening thrombosis. This study aimed to elucidate the roles of neutrophils and neutrophil extracellular traps (NETs) in vascular endothelial cell (EC) activation in pediatric MPP-associated thrombosis. We analyzed t...
Previous studies have shown that microbiota in the respiratory tract play a significant role in shaping host immunity and reducing the risk of respiratory tract infections. Influenza, an acute respiratory infectious disease caused by the influenza virus (IAV), necessitates to have an in-depth understanding of the patho...
Hai-Chang Yin, Xin-Yu Zhang, Song Liu et al.· Microbiome· 0 citations
Candida albicans (C. albicans) is a commensal fungus that can cause mucosal and systemic disease when host immunity or microbiota balance is disrupted. Hepcidin is a hepatic peptide hormone that degrades the iron exporter ferroportin, restricts extracellular iron availability, and forms a key component of nutritional i...
Thrisha Acharya, Tanmay Arekar, D. Katikaneni et al.· UF Journal of Undergraduate...· 0 citations
Streptococcus pneumoniae
(Spn) produces substantial amounts of hydrogen peroxide (H₂O₂), a metabolic byproduct with cytotoxic and immunomodulatory effects. Although pneumococcal H₂O₂ has been implicated in pathogenesis, its contribution to pulmonary immune responses and epithelial transcriptional responses dur...
Babek Alibayov, Xiao-Chen He, Ana G. Jop Vidal et al.· Respiratory Research· 0 citations
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