TL;DR
Results elucidate a novel IL-32γ-NF-κB-sEH regulatory cascade that facilitates macrophage-mediated bacterial clearance, thereby identifying a potential therapeutic target for the management of pneumococcal infections.
Rationale Dysregulated phagocytic clearance within the synovial microenvironment contributes to persistent inflammation and impairs immune homeostasis in rheumatoid arthritis (RA). Because MerTK-positive macrophages are essential for efferocytosis and inflammation resolution, but are functionally impaired in RA, this s...
IL-6 and MIP-2 played a role in PLY-induced PMN recruitment considering that this response was partially diminished in IL-66 gene deficient mice (P = 0.1 vs. wild type mice), and in mice treated with anti-MIP-2 antiserumm (P<0.05).
Anti-neutrophil cytoplasmic antibodies (ANCAs) target antigens in neutrophil granules, such as myeloperoxidase (MPO) or proteinase 3, causing small-vessel inflammation. ANCA pathogenicity is typically attributed to direct neutrophil activation, but a comprehensive understanding of its mode of action is lacking. In this...
Findings identify cell-intrinsic C3 as a suppressor of IFN-β production in human macrophages, highlighting the importance of the cell-intrinsic complement system in fine-tuning inflammatory responses to pathogens.
Introduction Neutrophil granulocytes (PMNs) play a crucial role in initial pathogen defense, in part through the release of neutrophil extracellular traps (NETs). These web-like structures are essential for pathogen clearance and preventing dissemination but can also elicit excessive inflammation resulting in tissue da...
Chronic infection by Echinococcus granulosus leads to the establishment of fluid-filled cysts (hydatid cysts) in the liver or lungs of infected hosts, which can escape destruction by the host immune system for long periods. Ag5 is abundantly expressed in the cyst fluid of the fine-grained E. granulosus and plays an imp...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
