IL-6 and MIP-2 played a role in PLY-induced PMN recruitment considering that this response was partially diminished in IL-66 gene deficient mice (P = 0.1 vs. wild type mice), and in mice treated with anti-MIP-2 antiserumm (P<0.05).
It is shown here that CD44 facilitates bacterial outgrowth and dissemination during pneumococcal pneumonia, which in lethal infection results in a prolonged survival of CD44 KO mice, and during sublethal pneumonia CD44 contributes to the resolution of the inflammatory response.
Systemic delivery of M(IL4) attenuated MHV-A59-induced inflammatory responses, as evidenced by reduced pro-inflammatory cytokine levels, decreased lung tissue damage, and enhanced viral clearance and pave the way for further investigation of macrophages as therapy for individuals with severe cases of respiratory viral...
F. B. Felix, V. A. Beltrami, Ana Paula Soares da Cruz Maravilha et al.· International Immunopharmaco...· 0 citations
RATIONALE
Pathogen-associated molecular patterns (PAMPs) are known to initiate pro-inflammatory responses, but emerging evidence has revealed their roles in inducing macrophage-dependent immunomodulatory pathways that dampen inflammation.
OBJECTIVES
We explored the interactions between the asthma-associated type 2 im...
Su-Na Rui, Seungmin Pyoa, Erin Warda et al.· American Journal of Respirat...· 0 citations
OPN levels are rapidly increased in the bronchoalveolar space during K. pneumoniae pneumonia, where OPN serves a chemotactic function towards neutrophils, thereby facilitating an effective innate immune response.
The data indicate that IRAK-M impairs host defense during pneumonia caused by two common respiratory pathogens, including Klebsiella pneumonia and Streptococcus pneumonia.
Results elucidate a novel IL-32γ-NF-κB-sEH regulatory cascade that facilitates macrophage-mediated bacterial clearance, thereby identifying a potential therapeutic target for the management of pneumococcal infections.
Longying Liang, Tingting Li, Weiwei Zhang et al.· Journal of Leukocyte Biology· 0 citations
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