TL;DR
GEO nano-emulgel demonstrated promising adjunctive therapeutic potential for periodontitis by improving clinical outcomes and significantly reducing inflammatory RANKL levels compared with GS gel.
Periodontal disease remains a major oral health burden and conventional scaling and root planing (SRP) alone often fails to achieve sustained outcomes in advanced cases. Therefore, it is of interest to evaluate the neem based local drug delivery (LDD) formulations including gel, chips and extract irrigation as adjuncts...
MSPs-loaded in situ gel represents a promising vehicle for MTZ to treat periodontitis and in vivo studies on rats revealed that this gel is an effective and innovative approach to treating periodontitis.
Objective: To evaluate the clinical and biochemical effects of local drug delivery (LDD) of ozonated sunflower seed oil formulations as adjuncts to mechanical debridement in patients with stage II periodontitis.Materials and methods: In this randomized controlled clinical trial, 75 participants were allocated into fiv...
Objectives: The purpose of this study was to assess the clinical efficacy of locally administered CMWP gel as a supplement to PMPD in individuals with Stage II Grade B periodontitis. Methods: Thirty patients with Stage II Grade B periodontitis who were systemically healthy and between the ages of 18 and 40 were divided...
Local herbal drug delivery may enhance non-surgical periodontal therapy by sustaining anti-inflammatory and antimicrobial activity at periodontal sites. This study randomized 15 systemically healthy patients aged 30-60 years to scaling and root planing (SRP) alone, SRP plus curcumin gel, or SRP plus propolis gel and re...
To evaluate and compare the clinical and microbiological efficacy of locally administered 1.2% Rosuvastatin (RSV) gel and 1.2% Simvastatin (SMV) gel as an adjunct to scaling and root planing (SRP) in the treatment of patients with chronic periodontitis. In this exploratory comparative study, 60 qualifying periodontal p...
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