Current therapeutic interventions to target cancer stem cells for metastasis

Review Open access Aug 2026

Translational insights and clinical challenges of targeting cancer stem cells

Cancer stem cells (CSCs) are tumor cell subsets with self-renewal, multilineage differentiation, and tumor-initiating capacity that sustain cancer initiation, progression, metastasis, and relapse. Targeting CSCs therefore represents a promising route to improve the durability of cancer treatment. However, translation o...

Mehreen Ahmed, A. Al-haidari, S. Agarwal et al. · Signal Transduction and Targ... · 0 citations

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Review Open access 2026

Emerging therapeutic targets in breast cancer: From molecular mechanisms to future perspectives

Introduction: Breast cancer is the most common malignancy in women and a major cause of mortality worldwide. Despite advances in treatment, therapeutic resistance and disease heterogeneity continue to limit the success of existing therapeutic approaches. Therefore, the identification of novel therapeutic targets has be...

Stela Novak, I. Kolarov-Bjelobrk, Marko Marjanovic et al. · Archive of Oncology · 0 citations

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Review Aug 2026

Drug resistance in breast cancer brain metastasis: mechanisms and therapeutic strategies.

This comprehensive review highlights BMBC resistance mechanisms, drawing from preclinical models, clinical studies, and genomic analyses, and highlights the potential for personalized, multi-targeted approaches to improve patient outcomes in BMBC.

Paromita Sarker, Shreyas S. Rao · Biochimica et biophysica act... · 0 citations

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Review Open access 2026

Breast cancer stem cells: drivers of progression and therapeutic resistance

Plastic features of BCSCs are summarized, their roles in metastasis and multidrug resistance, microenvironmental regulation and relevant therapeutic targeting strategies are summarized and progress toward subtype-specific combination approaches is indicated.

Mu-Yao Li, Ying Zhou, Xin-Qi Liu et al. · Cancer Advances · 0 citations

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Review Open access Aug 2026

Modern Therapies: Nanotechnology Promises New Approaches for Rare Breast Cancer to Brain Metastases.

This comprehensive review delves into recent advances in modern therapeutic approaches that aim to enhance the efficacy of conventional treatments for rare brain metastases from breast cancer and systematically evaluates emerging strategies such as advanced drug delivery technologies, including nanoparticles (NPs), pol...

Ghazala Muteeb, Aya Y El-Sayed, Mohamed S. AboHoussien et al. · SLAS discovery : advancing l... · 0 citations

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Review Sep 2026

Exploring the Role of Stem Cells in Cancer Therapy, Highlighting the risk-benefit Analysis

Conventional cancer treatments frequently fail because of metastasis, resistance, and serious side effects, making it one of the major causes of death globally. Because of their special qualities, including their capacity to target tumors, modulate the immune system, and promote regeneration, stem cell-based treatments...

Sanchari Bhattacharya, Ishita Debnath, Rajarshi Kasyapi et al. · Research Journal of Pharmacy... · 0 citations

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