AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
A library-immobilized SELEX strategy was employed to isolate DNA aptamers capable of recognizing both MPA and MMF, and a dual-recognition aptamer (MPA-1) exhibited specific binding toward MPA and MMF, demonstrating excellent selectivity.
ThT fluorescence is a useful label-free method to study voriconazole aptamers and that aptamers can be used to probe target binding to nanoscale host molecules and that aptamers can be used to probe target binding to nanoscale host molecules.
Dextromethorphan (DXM) is a widely used cough suppressant, and its escalating abuse is a pressing global health concern that necessitates rapid screening tools. However, rapid methods for detecting DXM in complex matrices remain highly limited. Here, we report the first isolation and engineering of DNA aptamers speci...
Background Venetoclax and selinexor are essential targeted agents for hematological malignancies, but their clinical application is challenged by pronounced ethnic pharmacokinetic differences—especially in Chinese patients—and CYP3A-mediated drug-drug interactions (DDIs) with azole antifungals (voriconazole, fluconazol...
This novel analytical method provides a sufficient quantitative range for the bioanalysis of nivolumab, thus offering a robust, specific, and cost-effective alternative for future pharmacokinetic studies.
Aflatoxin M1 (AFM1) in milk poses significant health risks due to its carcinogenicity and resistance to thermal processing. Here, we applied a computer-aided hapten design strategy integrating density functional theory, molecular docking, and molecular dynamics simulations to engineer four AFM1 haptens with tailored sp...
Chebulinic acid is a bioactive hydrolyzable tannin of increasing interest in natural product research, quality control, and pharmaceutical studies. In this work, four candidate DNA aptamers were identified using a restriction endonuclease-assisted SELEX (REase-SELEX) strategy, and Aptamer 1 was selected based on it...
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