Thrombosis and Haemostasis Clinical Validation of a Point-of-Care Whole Blood Coagulometer in Patients on Factor Xa Inhibitors

Heparin-calibrated anti-factor Xa activity as a surrogate marker for direct oral anticoagulant levels in acute stroke care: a large observational single-center study

Defined anti-Xa cut-offs are highly specific and sensitive and enable rapid and standardized assessment of anticoagulant activity in this cohort and Heparin-calibrated anti-Xa activity is a reliable surrogate marker for clinically relevant DOAC levels.

Real-World Assessment of Direct Oral Factor Xa Inhibitors: Dosing Appropriateness, Drug Exposure, and Inter-Platform Comparability of Chromogenic Anti-Xa Assays

Real-world outpatient DOAC concentrations demonstrated substantial variability and frequent off-label underdosing; these findings may nonetheless support individualized interpretation of outpatient spot sample DOAC concentrations in selected clinical settings.

The Safety of Pre-Filter Heparin for Circuit Clotting Prevention in Continuous Renal Replacement Therapy: A Retrospective Evaluation

Background: Circuit clotting is a common complication of continuous renal replacement therapy (CRRT). Pre-filter unfractionated heparin (UFH) is widely used to maintain circuit patency, but real-world data describing its safety and efficacy are limited. Methods: This retrospective, single-health-system study evaluated...

Assessment of Thrombin Generation in Pediatric Patients on Extracorporeal Life Support: Impact of Bivalirudin and Other Anticoagulants.

TGA shows promise in evaluating bivalirudin anticoagulation and is capable of detecting anticoagulant activity across both subtherapeutic and therapeutic levels of other agents commonly used in pediatric patients.

Saline whole-blood impedance aggregometry for detection of heparin-independent platelet-activating anti-platelet factor 4 antibodies.

Impact of a 15-minute incubation on citrated TEG (thromboelastography) results in adult surgical patients-a prospective observational study.

A 15-minute incubation significantly shortens CK-R/CKH-R and marginally decreases CK-MA, potentially normalizing hyper- or hypocoagulable readings, and strict adherence to the manufacturer's incubation protocol is recommended except in emergencies.